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Previously there were five sections, but the present edition has seven sections plus an appendix. The seven sections are 'General Principles of Toxicology' (Unit 1), 'Disposition of Toxicants' (Unit 2), 'Non organ-Directed Toxicity' (carcinogenicity, mutagenicity, and teratogenicity) (Unit 3), 'Target Organ Toxicity' (Unit 4), 'Toxic Agents' (Unit 5), 'Environmental Toxicology' (Unit 6), and 'Applications of Toxicology' (Unit 7). Without permitting the fifth edition to become unwidly in size and prohibitive in cost, we have added three new chapters: 'Toxicokinetics, Mechanisms of Toxicity', and 'Toxic Responses of the Endocrine System', as well as an Appendix on 'Recommended Limits for Exposure to Chemicals'. Half of the 34 chapters of the fifth edition have been written by authors not associated with the fourth edition. The fifth edition of Casarett and Doull's Toxicology: The Basic Science of Poisons marks its twentieth anniversary. The fifth edition, as the previous four, is meant to serve primarily as a text for, or an adjunct to, graduate courses in toxicology. Because the four previous editions have been widely used in courses in environmental health and related areas, an attempt has been made to maintain those characteristics that make it useful to scientists from other disciplines. This edition will again provide information on the many facets of toxicology and especially on the principles, concepts, and modes of thought that are the foundation of the discipline. Mechanisms of toxicity are emphasised. Research toxicologists will find this book an excellent reference source to find updated material in areas of their special or peripheral interests.While the overall framework of the fifth edition is similar to the previous four, it has undergone some significant changes. The fifth edition reflects the marked progress made in toxicology this decade. For example, the importance of apoptosis, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, transcription factors, transgenic animals, polymorphisms, etc.

Toxicology --- Poisoning --- Poisons --- Toxicologie --- Empoisonnement --- Poisoning. --- Poisons. --- Chemicals --- Medicine --- Pharmacology --- Poisonings --- Pharmaceutical Preparations --- poisoning --- Toxicology. --- 612.8 --- toxicologie (gez) --- Poison --- POISONING --- POISONS --- ENVIRONMENTAL POLLUTANTS --- TOXICOLOGY --- DIAGNOSIS --- METABOLISM --- TOXICITY

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579.67 --- 615.918 --- 615.918 Vegetable poisons. Fungal poisons. Mycotoxins. Aflatoxins --- Vegetable poisons. Fungal poisons. Mycotoxins. Aflatoxins --- 579.67 Food microbiology --- Food microbiology --- Agrotechnology and Food Sciences. Food Sciences --- Food Microbiology. --- Food contamination. --- Food poisoning. --- Food --- Microbiology. --- Food parasitology

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Mathematical statistics --- Toxicology --- -Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Statistical methods --- Statistical methods. --- -Statistical methods

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Chemical weapons disposal --- Chemical agents (Munitions) --- Chemical warfare agents --- Chemical weapons --- Poisons

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Hazardous substances --- Hazardous Substances --- Occupational Diseases --- Poisons --- Handbooks, manuals, etc --- poisoning --- chemically induced